Menopause marks a significant transition in a woman’s life, often accompanied by changes that affect muscle strength, bone health, cognitive function, and sleep quality. Recent research shines a spotlight on creatine, a supplement traditionally associated with athletic performance, as a promising ally for menopausal women facing these challenges. This article unpacks the latest findings on how creatine supports health during menopause, why it benefits cognition and sleep, and provides practical guidance for supplementation.
What did the study find?
A recent study, involving women who took 5 grams of creatine daily alongside twice-weekly resistance training over 14 weeks, revealed notable improvements in muscle strength, particularly in the lower body, and enhanced body composition. Importantly, women reported better sleep quality with fewer nighttime awakenings. Cognitive function also showed gains, with one-third of postmenopausal participants shifting from mild cognitive impairment to normal cognitive scores—a change considered clinically significant. The study’s lead author, Lauren Hall, emphasized that while creatine’s muscle benefits are well-known, its positive impact on sleep and brain health amid menopause is especially encouraging.
Why does creatine support cognitive health and sleep?
Creatine enhances brain energy metabolism by boosting the production of adenosine triphosphate (ATP), the molecule that fuels cellular activities. During menopause, fluctuations and declines in estrogen affect neurotransmitters and brain function, often resulting in brain fog and sleep disturbances. Creatine supplementation appears to stabilize sleep patterns and support cognitive resilience by improving energy availability for brain cells. This aligns with emerging evidence linking creatine to neuroprotection and improved mental focus, memory, and decision-making.
Benefits of creatine for menopausal women
Creatine offers multiple benefits, particularly when paired with resistance exercise—a powerful combination for women facing menopausal changes:

- Muscle mass and strength maintenance: Menopause can accelerate muscle loss by about 8% per decade after 30, compounded by lowered estrogen. Creatine urges muscle repair and growth by increasing ATP production, improving muscle hydration, and stimulating protein synthesis. This counters the sarcopenia (muscle wasting) common during menopause, supporting mobility and everyday strength.
- Bone health support: Creatine reduces inflammation and oxidative stress that contribute to bone degradation. It also enhances osteoblast activity, promoting bone formation and helping prevent osteoporosis risks.
- Mood and cognitive support: Higher spinal fluid creatine levels correlate with improved dopamine and serotonin regulation, essential for mood stability. Women report better focus, reduced mental fatigue, and sharper cognitive performance.
- Sleep improvement: Studies show creatine may enhance sleep quality by aiding brain energy metabolism and reducing sleep disruptions common in menopause.
Are there any side effects to taking creatine?
Creatine is generally regarded as safe and well-tolerated in menopausal women when taken at recommended doses. Side effects are rare but may include mild digestive discomfort, especially if large “loading” doses are taken initially. Long-term use at moderate doses (3-5 grams daily) has not shown adverse effects in clinical research. Individuals with kidney disease or other health conditions should consult healthcare professionals before starting supplementation.
How much creatine should you take a day?
The consensus among experts is that menopausal women benefit most from a daily dose of 3 to 5 grams of creatine monohydrate. This amount effectively saturates muscle and brain stores to achieve health benefits without notable side effects. Consistency is critical; daily intake maintains elevated creatine levels, whether on active or rest days. Some women may prefer to start at the lower end and gradually increase as tolerated.
Should you take creatine even if you don’t lift weights?
Yes, even for those not engaged in resistance training, creatine supplementation can support cognitive function, mood, and sleep quality. Although the muscle and bone benefits are maximized with exercise, creatine provides cellular energy support throughout the body, including the brain. Thus, its advantages extend beyond weightlifting or athletic endeavors, making it a sensible option during menopause regardless of activity level.
The bottom line
Creatine, long celebrated in sports nutrition, is emerging as a versatile supplement to address key health concerns faced by menopausal women. By enhancing muscle strength, bone density, cognitive function, and sleep quality, creatine offers a promising supplement that is both safe and affordable. As Lauren Hall, the study’s lead author, notes, “While creatine is one of the most researched supplements in sports nutrition, there’s a noticeable lack of data on how it impacts women during midlife and hormonal transition.” This new research begins to fill that gap, suggesting creatine could be a transformative addition to menopausal health strategies.

For women navigating menopause, creatine supplementation may not only support everyday strength and resilience but also improve brain health and restfulness, contributing to a higher quality of life during this pivotal life stage. Before starting any new supplement, discussing options with a healthcare provider ensures safety and personalized guidance.
Also Read | How Posture Walking Transforms Your Daily Health Routine