Study Says Cognitive Decline Is Linked to a Reduced Hippocampus Size

Study Says Cognitive Decline Is Linked to a Reduced Hippocampus Size – New Study Provides Insights into the Role of Hippocampal Atrophy

A recent study published in the journal Neurology has provided new insights into the relationship between hippocampal atrophy and cognitive decline. The study found that even individuals without brain amyloid plaques, the hallmark protein deposits associated with Alzheimer’s disease, may experience cognitive decline due to shrinkage in the hippocampus, a brain region crucial for memory formation. The study also found that a higher rate of hippocampal atrophy is linked to a faster rate of cognitive deterioration.

Study Says Cognitive Decline Is Linked to a Reduced Hippocampus Size
Study Says Cognitive Decline Is Linked to a Reduced Hippocampus Size

Study Findings

The study involved 128 participants whose average age was 72. At the beginning of the study, none of the participants had any cognitive or memory problems. The participants underwent annual cognitive tests for an average follow-up period of seven years. Throughout the study, the participants also had a variety of brain scans to determine the volume of the hippocampus and the number of tau tangles and amyloid plaques in their brains.

The researchers found that individuals with a faster rate of hippocampal atrophy experienced a more rapid decline in cognitive function. This was true even after controlling for the presence of tau and amyloid plaques. The researchers also found that simply reducing the hippocampus area explained 10% of the variation in cognitive deterioration.

Implications of the Study Findings

The findings of this study have several important implications. First, they suggest that hippocampal atrophy may play a role in cognitive decline even in individuals without Alzheimer’s disease. Second, they suggest that measuring hippocampal volume may be a useful tool for predicting individual responses to new Alzheimer’s treatments and the rate of cognitive deterioration.


This study is an important step forward in our understanding of the causes of cognitive decline. The findings suggest that hippocampal atrophy may be a common cause of cognitive decline, even in individuals without Alzheimer's disease. Further research is needed to understand the mechanisms by which hippocampal atrophy leads to cognitive decline.

Risk factors

In addition to the findings of this study, there are a number of other risk factors for cognitive decline, including:

Head trauma
Education level
Lifestyle factors such as diet, exercise, and smoking

By identifying and addressing these risk factors, we may be able to prevent or delay the onset of cognitive decline.

What Is Hippocampus?

The hippocampus is a small but complex brain structure that plays a critical role in memory formation, spatial navigation, and emotional regulation. It is located deep within the temporal lobe of the brain and is shaped like a seahorse, hence its name, which derives from the Greek words “hippos” meaning horse and “kampos” meaning sea monster.

Key Functions of the Hippocampus

  1. Memory Formation: The hippocampus is essential for converting short-term memories into long-term memories. It works by consolidating new information and linking it to existing memories, allowing us to retain and retrieve information over time.

  2. Spatial Navigation: The hippocampus helps us create and maintain a mental map of our surroundings, enabling us to navigate our environment effectively. It plays a crucial role in spatial processing, allowing us to understand our position in relation to objects and landmarks.

  3. Emotional Regulation: The hippocampus is also involved in emotional processing and regulation. It interacts with other brain structures, such as the amygdala, to regulate emotional responses and influence our emotional memories.

Hippocampus and Neurological Disorders

Damage to the hippocampus can lead to a range of cognitive impairments, including memory loss, disorientation, and difficulties with emotional regulation. Several neurological disorders, including Alzheimer’s disease, epilepsy, and temporal lobe epilepsy, are associated with hippocampal damage.

Alzheimer’s Disease: One of the most common causes of hippocampal damage is Alzheimer’s disease. In Alzheimer’s, the hippocampus is affected by the buildup of amyloid plaques and tau tangles, which disrupt neuronal communication and lead to memory loss and cognitive decline.

Epilepsy: Hippocampal damage can also occur in individuals with epilepsy, particularly temporal lobe epilepsy. This type of epilepsy is characterized by seizures that originate from the temporal lobe, and damage to the hippocampus can contribute to memory problems and other cognitive impairments.

Research and Future Directions

Researchers continue to investigate the intricate workings of the hippocampus and its role in various neurological conditions. Understanding the mechanisms underlying hippocampal function and its susceptibility to damage is crucial for developing effective treatments for disorders that affect memory, spatial navigation, and emotional regulation.


Hanseeuw, B. J., et al. (2020). Hippocampal atrophy predicts cognitive decline in the absence of amyloid plaques and tau tangles. Neurology, 95(8), e1117-e1125.

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