In another study, the cause as to why exercise may be difficult for some who are taking statins was looked at.

According to the researchers, statin therapy could alter calcium handling such that calcium leaking might be impaired.

“For example, two months treatment of rats with fluvastatin and atorvastatin caused an alteration of calcium homeostasis, increasing resting cytosolic calcium up to 60 percent,” noted the study.

It added: “Since animal research suggests that type II glycolytic muscle fibres are most vulnerable to statin associated muscle injury following cervistatin treatment and treadmill exercise in female rats, carbohydrate depletion during exercise could make these fibres particularly susceptible to injury in humans as well.”

It concluded: “Differences in fibre type composition between individuals may also consequently impact muscle response to the combination of statin and exercise.”

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